Reaction Details Report a problem with these data
Target
Neuromedin-U receptor 2
Ligand
BDBM50238690
Substrate
n/a
Meas. Tech.
ChEMBL_1664054 (CHEMBL4013735)
EC50
0.056000±n/a nM
Citation
 Kanematsu-Yamaki, Y; Nishizawa, N; Kaisho, T; Nagai, H; Mochida, T; Asakawa, T; Inooka, H; Dote, K; Fujita, H; Matsumiya, K; Hirabayashi, H; Sakamoto, J; Ohtaki, T; Takekawa, S; Asami, T Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide. J Med Chem 60:6089-6097 (2017) [PubMed]  Article 
Target
Name:
Neuromedin-U receptor 2
Synonyms:
NMU-R2 | NMUR2_MOUSE | Neuromedin-U receptor 2 | Nmur2
Type:
PROTEIN
Mol. Mass.:
44839.20
Organism:
Mus musculus
Description:
ChEMBL_109541
Residue:
395
Sequence:
MGKLENASWIHDSLMKYLNSTEEYLAYLCGPKRSDLSLPVSVVYALIFVVGVIGNLLVCLVIARHQTLKTPTNYYLFSLAVSDLLVLLLGMPLEVYELWHNYPFLFGPVGCYFKTALFETVCFASILSVTTVSIERYVAIVHPFRAKLESTRRRALRILSLVWSFSVVFSLPNTSIHGIKFQQFPNGSSVPGSATCTVTKPIWVYNFIIQATSFLFYILPMTLISVLYYLMGLRLKRDESLEADKVTVNIHRPSRKSVTKMLFVLVLVFAICWTPFHVDRLFFSFVDEWTESLAAVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRAAFRNVVSPSCKWCHPQHRPQGPPAQKVIFLTECHLVELTEDAGPQFPCQSSIHNTQLTTVPCVEEVP
  
Inhibitor
Name:
BDBM50238690
Synonyms:
CHEMBL4068681
Type:
Small organic molecule
Emp. Form.:
C60H88N18O11
Mol. Mass.:
1237.4547
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r|
Structure:
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