Reaction Details Report a problem with these data
Target
Neuromedin-U receptor 1
Ligand
BDBM50238689
Substrate
n/a
Meas. Tech.
ChEMBL_1664053 (CHEMBL4013734)
EC50
0.690000±n/a nM
Citation
 Kanematsu-Yamaki, Y; Nishizawa, N; Kaisho, T; Nagai, H; Mochida, T; Asakawa, T; Inooka, H; Dote, K; Fujita, H; Matsumiya, K; Hirabayashi, H; Sakamoto, J; Ohtaki, T; Takekawa, S; Asami, T Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide. J Med Chem 60:6089-6097 (2017) [PubMed]  Article 
Target
Name:
Neuromedin-U receptor 1
Synonyms:
G-protein coupled receptor 66 | G-protein coupled receptor FM-3 | Gpr66 | NMU-R1 | NMUR1_MOUSE | Nmur1
Type:
n/a
Mol. Mass.:
47951.94
Organism:
Mus musculus
Description:
n/a
Residue:
428
Sequence:
MTPPCLNCSIFPGALSPNASRSPLVCNISEFKWPYQPEDLNLTDEALRLKYLGPQQMKQFVPICVTYLLIFVVGTLGNGLTCTVILRNKTMRTPTNFYLFSLAVSDMLVLLVGLPLELYEMQQNYPFQLGASACYFRILLLETVCLASVLNVTALSVERYVAVVRPLQAKSVMTRAHVRRMVGAIWVLATLFSLPNTSLHGLSQLTVPCRGPVPDSAICSLVGPMDFYKLVVLTTALLFFCLPMVTISVLYLLIGLRLRRERMLLQVEVKGRKTAATQETSHRRIQLQDRGRRQVTKMLFALVVVFGICWAPFHADRIMWSLVYGHSTEGLHLAYQCVHIASGIFFYLGSAANPVLYSLMSTRFRETFLQALGLGTQCCHRRQPYHGSHNHIRLTTGSTLCDVGHRNSRDEPLAVNEDPGCQQETDPS
  
Inhibitor
Name:
BDBM50238689
Synonyms:
CHEMBL4073946
Type:
Small organic molecule
Emp. Form.:
C55H81N17O11
Mol. Mass.:
1156.3389
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r|
Structure:
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