Reaction Details Report a problem with these data
Target
Heme oxygenase 1
Ligand
BDBM84847
Substrate
n/a
Meas. Tech.
Heme Oxygenase
pH
7.4±0
Temperature
298.15±0 K
IC50
7e+2± 4e+2 nM
Citation
 Roman, G; Rahman, MN; Vukomanovic, D; Jia, Z; Nakatsu, K; Szarek, WA Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone. Chem Biol Drug Des 75:68-90 (2010) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1
Type:
Enzyme
Mol. Mass.:
33005.15
Organism:
Rattus norvegicus (rat)
Description:
HO-1 obtained from rat spleen was used in enzyme assays.
Residue:
289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
  
Inhibitor
Name:
BDBM84847
Synonyms:
1-azolyl-4-phenyl-2-butanone, 49a | CHEMBL558183
Type:
n/a
Emp. Form.:
C15H18N2O2
Mol. Mass.:
258.3156
SMILES:
C(CC1(Cn2ccnc2)OCCO1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: