Reaction Details Report a problem with these data
Target
Heme oxygenase 2
Ligand
BDBM84833
Substrate
n/a
Meas. Tech.
Heme Oxygenase
pH
7.4±0
Temperature
298.15±0 K
IC50
>1.00e+5±n/a nM
Citation
 Roman, G; Rahman, MN; Vukomanovic, D; Jia, Z; Nakatsu, K; Szarek, WA Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: effect of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone. Chem Biol Drug Des 75:68-90 (2010) [PubMed]  Article 
Target
Name:
Heme oxygenase 2
Synonyms:
HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2
Type:
Enzyme
Mol. Mass.:
35754.99
Organism:
Rattus norvegicus (rat)
Description:
HO-2 obtained from rat brain was used in enzyme assays.
Residue:
315
Sequence:
MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENWEEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAGSMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILAASVALVAGLLAWYYM
  
Inhibitor
Name:
BDBM84833
Synonyms:
1-azolyl-4-phenyl-2-butanone, 35
Type:
n/a
Emp. Form.:
C13H15N3OS
Mol. Mass.:
261.343
SMILES:
CSc1ncnn1CC(=O)CCc1ccccc1
Structure:
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