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Target
Gamma-aminobutyric acid receptor subunit alpha-1
Ligand
BDBM50017009
Substrate
n/a
Ki
0.11±n/a nM
Comments
PDSP_502
Citation
 Scholze, P; Ebert, V; Sieghart, W Affinity of various ligands for GABAA receptors containing alpha 4 beta 3 gamma 2, alpha 4 gamma 2, or alpha 1 beta 3 gamma 2 subunits. Eur J Pharmacol 304:155-62 (1996) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-1
Synonyms:
Benzodiazepine central | GABA A Benzodiazepine brain | GABA A Benzodiazepine liver | GABA receptor alpha-1 subunit | GABA(A) receptor subunit alpha-1 | GABA-A | GABA-A receptor | GABRA1 | GBRA1_HUMAN | Gamma-aminobutyric acid receptor subunit alpha (GABAA) | TBPS | agonist GABA site
Type:
Protein
Mol. Mass.:
51817.35
Organism:
Homo sapiens (Human)
Description:
P14867
Residue:
456
Sequence:
MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
  
Inhibitor
Name:
BDBM50017009
Synonyms:
2-Phenyl-2,3a-dihydro-pyrazolo[4,3-c]quinolin-3-one(CGS 8216) | 2-Phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one | 2-Phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one (CGS 8216) | 2-Phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one(CGS 8216) | 2-Phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one(CGS-8216) | 2-phenyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-one | CGS 8216, 1 | CGS-8216 | CHEMBL19732
Type:
Small organic molecule
Emp. Form.:
C16H11N3O
Mol. Mass.:
261.278
SMILES:
O=c1n([nH]c2c1cnc1ccccc21)-c1ccccc1
Structure:
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