Reaction Details
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5-hydroxytryptamine receptor 4
Ligand
BDBM50007871
Substrate
n/a
Ki
544±n/a nM
Comments
PDSP_956
Citation
Adham, N; Gerald, C; Schechter, L; Vaysse, P; Weinshank, R; Branchek, T [3H]5-hydroxytryptamine labels the agonist high affinity state of the cloned rat 5-HT4 receptor. Eur J Pharmacol 304:231-5 (1996) [PubMed] Article More Info.:
Target
Name:
5-hydroxytryptamine receptor 4
Synonyms:
5-HT-4 | 5-HT4 | 5-HT4L | 5-HT4S | 5-hydroxytryptamine receptor 4 | 5HT4R_RAT | Htr4 | Serotonin (5-HT) receptor | Serotonin 4 (5-HT4) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46117.31
Organism:
RAT
Description:
5-HT4 HTR4 RAT::Q62758
Residue:
406
Sequence:
MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
Inhibitor
Name:
BDBM50007871
Synonyms:
CHEMBL8197 | ICS 205-930 | TROPISETRON
Type:
Small organic molecule
Emp. Form.:
C17H20N2O2
Mol. Mass.:
284.3529
SMILES:
CN1C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12 |THB:9:7:1:3.4|
Structure:
