Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM274918
Substrate
n/a
Meas. Tech.
Intracellular Calcium Assay
IC50
43.0±n/a nM
Citation
 Kuduk, SD; Skudlarek, JW Piperidinyloxy lactone orexin receptor antagonists US Patent  US9556190 Publication Date 1/31/2017 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM274918
Synonyms:
1,1-dimethyl-4-{[(3R,6R)-6-methyl-1- {[3-methyl-2-(2H-1,2,3-triazol-2- yl)phenyl]carbonyl}piperidin-3- yl]oxy}furo[3,4-c]pyridin-3(1H)-one | US9556190, Example 8
Type:
Small organic molecule
Emp. Form.:
C25H27N5O4
Mol. Mass.:
461.513
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1cccc(C)c1-n1nccn1)Oc1nccc2c1C(=O)OC2(C)C |r|
Structure:
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