Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM274943
Substrate
n/a
Meas. Tech.
Intracellular Calcium Assay
IC50
20.0±n/a nM
Citation
 Kuduk, SD; Skudlarek, JW Piperidinyloxy lactone orexin receptor antagonists US Patent  US9556190 Publication Date 1/31/2017 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM274943
Synonyms:
4-{[(3R,6R)-6- methyl- 1-({2-[(methyl- sulfonyl)methyl]- phenyl}carbonyl)- piperidin- 3-yl]oxy}furo[3,4- c]pyridin-1(3H)-one | US9556190, Example 33
Type:
Small organic molecule
Emp. Form.:
C22H23FN2O6S
Mol. Mass.:
462.491
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1CS(C)(=O)=O)Oc1nccc2C(=O)OCc12 |r|
Structure:
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