Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 5

Ligand

BDBM82290

Substrate

n/a

4.2±n/a nM

Comments

PDSP_3393

Citation

Hu, Y; Bloomquist, BT; Cornfield, LJ; DeCarr, LB; Flores-Riveros, JR; Friedman, L; Jiang, P; Lewis-Higgins, L; Sadlowski, Y; Schaefer, J; Velazquez, N; McCaleb, ML Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J Biol Chem 271:26315-9 (1996) [PubMed] Article

More Info.:

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Target

Name:

Neuropeptide Y receptor type 5

Synonyms:

NPY-Y5 | NPY5R_RAT | Neuropeptide Y receptor type 5 | Npy5r | Npyr5

Type:

Enzyme Catalytic Domain

Mol. Mass.:

50435.58

Organism:

Rat 6B

Description:

NPY-Y5 NPY5R Rat 6B::Q63634

Residue:

445

Sequence:

MEFKLEEHFNKTFVTENNTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLQPSKKSRNQAKTPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQGKHLAVPENPASVRSQLSPSSKVIPGVPICFEVKPEESSDAHEMRVKRSITRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS

Inhibitor

Name:

BDBM82290

Synonyms:

PYY 3-36, rat | PYY13-36, porcine

Type:

Small organic molecule

Emp. Form.:

C135H208N40O39

Mol. Mass.:

3015.3406

SMILES:

CC(C)C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O

Structure: