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Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM275024
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
3840±n/a nM
Comments
extracted
Citation
 Imbriglio, J; London, C; Lu, Z; Tata, J; Xiong, Y; You, M; Youm, H Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent  US9877957 Publication Date 1/30/2018 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM275024
Synonyms:
N8-(1-(4H-1,2,4-triazol-3-yl)ethyl)-N2-(tert- butyl)-5-(3-(trifluoromethyl)phenyl)-3,4- dihydroisoquinoline-2,8(1H)-dicarboxamide | US9877957, Example 62
Type:
Small organic molecule
Emp. Form.:
C26H29F3N6O2
Mol. Mass.:
514.5427
SMILES:
CC(NC(=O)c1ccc(-c2cccc(c2)C(F)(F)F)c2CCN(Cc12)C(=O)NC(C)(C)C)c1nnc[nH]1
Structure:
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