Reaction Details
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Gamma-aminobutyric acid receptor subunit alpha-4
Ligand
BDBM50034835
Substrate
n/a
Ki
6±n/a nM
Comments
PDSP_1606
Citation
Gunnersen, D; Kaufman, CM; Skolnick, P Pharmacological properties of recombinant "diazepam-insensitive" GABAA receptors. Neuropharmacology 35:1307-14 (1996) [PubMed] Article More Info.:
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-4
Synonyms:
GBRA4_RAT | Gabra4 | Gamma-aminobutyric acid receptor (GABA(A)) subunit alpha-4
Type:
Enzyme
Mol. Mass.:
60972.37
Organism:
Rattus norvegicus (Rat)
Description:
P28471
Residue:
552
Sequence:
MVSVQKVPAIVLCSGVSLALLHVLCLATCLNESPGQNSKDEKLCPENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMQKAKKKISKPPPEVPAAPVLKEKHTETSLQNTHANLNMRKRTNALVHSESDVNSRTEVGNHSSKTTAAQESSETTPKAHLASSPNPFSRANAAETISAAARGLSSAASPSPHGTLQPAPLRSASARPAFGARLGRIKTTVNTTGVPGNVSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKSESLM
Inhibitor
Name:
BDBM50034835
Synonyms:
5-Methyl-6-oxo-5,6-dihydro-4H-7-thia-2,5,9b-triaza-cyclopenta[e]azulene-3-carboxylic acid tert-butyl ester | CHEMBL269366 | Ro 19-4603 | Ro-19-4603
Type:
Small organic molecule
Emp. Form.:
C15H17N3O3S
Mol. Mass.:
319.379
SMILES:
CN1Cc2c(ncn2-c2ccsc2C1=O)C(=O)OC(C)(C)C
Structure:
