Reaction Details
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5-hydroxytryptamine receptor 2A
Ligand
BDBM85079
Substrate
n/a
Ki
240±n/a nM
Comments
PDSP_2284
Citation
Mos, J; Van Hest, A; Van Drimmelen, M; Herremans, AH; Olivier, B The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons. Eur J Pharmacol 325:145-53 (1997) [PubMed] Article More Info.:
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT2A | HTR2A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
105583.25
Organism:
pigeon
Description:
5-HT2A HTR2A pigeon::A0A1V4J4E5
Residue:
946
Sequence:
MGVFVKDSSDSAYLTPERKLALGRGKAQGKSRQAAYLSEEKNKPRSTGTGFTQVCSLEVKKLFQIPPFWRRLKKRDAKLAKHNEEYSESVQSEPNRILRVGSDVQPGFSMYAYTGLPMELKTKHFSIQSNSVSNFAMDILCDQESSVNPTAKSLIQINHERRLYRNVYGAGEINASHLFNLTVDSENLTNVSSESSVTPPCYSSLFQLSQKNWPALLTVIVIVLTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYAWPLPRKLCAIWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFAKIIAVWTISVGISMPVPVFGLQDDSKVFKKDSCLLADDNFVLVGSFVAFFIPLTIMVVTYFLTIKSLQKEAMLCVNDIGPKTKFASFSFLPQSSLSSEKLFQRSLNRDVGTSGRRTMQSISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVICKESCNQEVIGELLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCRYKEEKKPFQLILVNTIPALAYNSSQLQLAQMKSLKKEAKMMAKDYSMVTIGIHHLDGTSKGSISPVNENVSETAAQHPPWQTQTGRLRALPRSAGGPGRQAGRLEAAPARGQPPPPVLRRAAPPLLLVKAMALKQVSSNKCFEGFQKVFEHDSAELKCKMKFGIYLPPKAETGKCPVLYWLSGLTCTEQNFITKAGFHQAAAEHGLIVVAPDTSPRGCNIEGEDESWDFGTGAGFYVDATEDPWKTNYRMYSYIKDELPKLINANFPTDPERMSIFGHSMGGHGALILALKNPGKYKSVSAFAPICNPMQCQWGKKALGGYLGSDASKWEAYDATQLVKSYPDSHLDILIDQGKDDQFLSAGQLLPDNFIAACTERKIPVVFRLQQGYDHSYFFIATFINDHIKHHAKYLNA
Inhibitor
Name:
BDBM85079
Synonyms:
2-[4-[4-[(7-Chloro-2,3-dihydro-1,4-benzodioxin)-5-yl]-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide | CHEMBL79261 | DU-125530 | DU125530
Type:
Small organic molecule
Emp. Form.:
C23H26ClN3O5S
Mol. Mass.:
491.988
SMILES:
Clc1cc2OCCOc2c(c1)N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Structure:
