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Target
Alpha-2A adrenergic receptor
Ligand
BDBM85098
Substrate
n/a
Ki
316.22±n/a nM
Comments
PDSP_1626
Citation
 Bonhaus, DW; Weinhardt, KK; Taylor, M; DeSouza, A; McNeeley, PM; Szczepanski, K; Fontana, DJ; Trinh, J; Rocha, CL; Dawson, MW; Flippin, LA; Eglen, RM RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist. Neuropharmacology 36:621-9 (1997) [PubMed]  Article 
Target
Name:
Alpha-2A adrenergic receptor
Synonyms:
ADRA2A | Alpha 2A adrenoceptor | adrenergic Alpha2A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49324.71
Organism:
RABBIT
Description:
Q5ZQK3
Residue:
451
Sequence:
MGSLQPDAGNGSWNGSEAPGGGARASPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGQAWCEIYLALDMLFCTSSIAHLCAISLDRHWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIERKGGGGGGGRQRCEINDHKWYVIASCTGSFFVPCLIMILVYVRIYQIAKRRTRVPPSRRVRTPPPPPPPPPPPPRQPGPPSAGLMAWAPERGAGSASAETEPLPTQLNGAAGEPAAAGPRETDALDLEESSSSEHAERPPGPASRGPRQGPSEPGEARGQHPSARARDRGARGVGGRARGDTPEAPRRLWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
  
Inhibitor
Name:
BDBM85098
Synonyms:
N-[5-[5-(2,4-Dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-1-oxopentyl]-2,4-dimethoxyphenyl]-4-(trifluoromethyl)benzenesulfonamide | RS-102221
Type:
Small organic molecule
Emp. Form.:
C27H31F3N4O7S
Mol. Mass.:
612.618
SMILES:
[#6]-[#8]-c1cc(-[#8]-[#6])c(cc1-[#7][S;v6](=O)(=O)c1ccc(cc1)C(F)(F)F)-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]C2([#6]-[#6]-1)[#7]-[#6](=O)-[#7]-[#6]2=O
Structure:
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