Reaction Details Report a problem with these data
Target
Serotonin N-acetyltransferase
Ligand
BDBM85108
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
pH
6.8±0
Temperature
303.15±0 K
Ki
32±n/a nM
Citation
 Zheng, W; Cole, PA Novel bisubstrate analog inhibitors of serotonin N-acetyltransferase: the importance of being neutral. Bioorg Chem 31:398-411 (2003) [PubMed]  Article 
Target
Name:
Serotonin N-acetyltransferase
Synonyms:
AANAT | Aralkylamine N-acetyltransferase | SNAT | SNAT_HUMAN | Serotonin N-acetyltransferase (AANAT)
Type:
Protein
Mol. Mass.:
23350.36
Organism:
Homo sapiens (Human)
Description:
Q16613
Residue:
207
Sequence:
MSTQSTHPLKPEAPRLPPGIPESPSCQRRHTLPASEFRCLTPEDAVSAFEIEREAFISVLGVCPLYLDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLWDKERLMQESLTLHRSGGHIAHLHVLAVHRAFRQQGRGPILLWRYLHHLGSQPAVRRAALMCEDALVPFYERFSFHAVGPCAITVGSLTFMELHCSLRGHPFLRRNSGC
  
Inhibitor
Name:
BDBM85108
Synonyms:
AANAT bisubstrate analog, 3
Type:
Small organic molecule
Emp. Form.:
C35H51N8O17P3S
Mol. Mass.:
980.809
SMILES:
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1OC([C@@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12)[C@@H](O)C(=O)NCCC(=O)NCCSCCC(=O)CCCc1c[nH]c2ccccc12
Structure:
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