Reaction Details Report a problem with these data
Target
Homoserine kinase
Ligand
BDBM24941
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
7.5±0
Temperature
310.15±0 K
Ki
1.20e+4± 1.8e+3 nM
Citation
De Pascale, G; Griffiths, EJ; Shakya, T; Nazi, I; Wright, GD Identification and characterization of new inhibitors of fungal homoserine kinase. Chembiochem 12:1179-82 (2011) [PubMed] Article
More Info.:
Target
Name:
Homoserine kinase
Synonyms:
KHSE_ECOLI | thrB
Type:
Enzyme
Mol. Mass.:
33619.26
Organism:
Escherichia coli
Description:
P00547
Residue:
310
Sequence:
MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPETAQRVADWLGKNYLQNQEGFVHICRLDTAGARVLEN
Inhibitor
Name:
BDBM24941
Synonyms:
(2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methylidene}-3-oxobutanenitrile | CHEMBL228043 | LFM-A13 | Thr1 inhibitor, 2 | alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl)propenamide
Type:
Small organic molecule
Emp. Form.:
C11H8Br2N2O2
Mol. Mass.:
360.001
SMILES:
CC(=O)C(C#N)C(=O)Nc1cc(Br)ccc1Br