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Target
Homoserine kinase
Ligand
BDBM85123
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
7.5±0
Temperature
310.15±0 K
Ki
2.71e+4± 9e+2 nM
Citation
 De Pascale, G; Griffiths, EJ; Shakya, T; Nazi, I; Wright, GD Identification and characterization of new inhibitors of fungal homoserine kinase. Chembiochem 12:1179-82 (2011) [PubMed]  Article 
Target
Name:
Homoserine kinase
Synonyms:
KHSE_ECOLI | thrB
Type:
Enzyme
Mol. Mass.:
33619.26
Organism:
Escherichia coli
Description:
P00547
Residue:
310
Sequence:
MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPETAQRVADWLGKNYLQNQEGFVHICRLDTAGARVLEN
  
Inhibitor
Name:
BDBM85123
Synonyms:
Thr1 inhibitor, 3 | cid_235240
Type:
Small organic molecule
Emp. Form.:
C15H12O7
Mol. Mass.:
304.2516
SMILES:
OC1C(=O)C(Oc2cc(O)c(O)cc12)c1ccc(O)c(O)c1
Structure:
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