Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM275074
Substrate
n/a
Meas. Tech.
TNAP Inhibition Activity
Temperature
298.15±n/a K
IC50
6.20±n/a nM
Comments
extracted
Citation
 Miyazaki, SYamamoto, YSuzuki, KInui, MIzumi, MSoma, KPinkerton, AShinozaki, T Pyridine compounds US Patent  US9879032 Publication Date 1/30/2018 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM275074
Synonyms:
US10221195, Example 16 | US9879032, Example 16
Type:
Small organic molecule
Emp. Form.:
C17H18ClN3O5S
Mol. Mass.:
411.86
SMILES:
COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OCC(C)N(C)C(=O)c2c1
Structure:
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