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Target
Mitogen-activated protein kinase 1
Ligand
BDBM275165
Substrate
n/a
Meas. Tech.
IMAP-FP Assay
IC50
1.01±n/a nM
Citation
 Siliphaivanh, P; Methot, J; Lipford, KA; Molinari, D; Sloman, DL; Witter, D; Zhou, H; Boyce, C; Huang, X; Lim, J; Guerin, D; Karunakaran, GB; Bakshi, RK; Liu, Z; Fu, J; Wan, Z; Liu, W ERK inhibitors US Patent  US9884048 Publication Date 2/6/2018 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM275165
Synonyms:
1-[1-(2-methylpyridin-4-yl)- 1H-pyrazolo[3,4-c]pyridin- 5-yl]-3-[(1R)-1- phenylethyl]urea | US9884048, Example 59
Type:
Small organic molecule
Emp. Form.:
C21H20N6O
Mol. Mass.:
372.4231
SMILES:
C[C@@H](NC(=O)Nc1cc2cnn(-c3ccnc(C)c3)c2cn1)c1ccccc1 |r|
Structure:
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