Target
Mitogen-activated protein kinase 1
Ligand
BDBM275221
Substrate
n/a
Meas. Tech.
IMAP-FP Assay
IC50
0.18±n/a nM
Citation
 Siliphaivanh, PMethot, JLipford, KAMolinari, DSloman, DLWitter, DZhou, HBoyce, CHuang, XLim, JGuerin, DKarunakaran, GBBakshi, RKLiu, ZFu, JWan, ZLiu, W ERK inhibitors US Patent  US9884048 Publication Date 2/6/2018 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM275221
Synonyms:
1-[(3R,4S)-1-methyl-4-(2- phenylethyl)pyrrolidin-3- yl]-3-[1-(2-methylpyridin-4- yl)-1H-pyrazolo[3,4-c]- pyridin-5-yl)urea | US9884048, Example 115 | US9884048, Example 185
Type:
Small organic molecule
Emp. Form.:
C26H29N7O
Mol. Mass.:
455.5548
SMILES:
CN1C[C@H](CCc2ccccc2)[C@H](C1)NC(=O)Nc1cc2cnn(-c3ccnc(C)c3)c2cn1 |r|
Structure:
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