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TargetNociceptin/Orphanin FQ, NOP receptor
LigandBDBM85194
Substrate/Competitorn/a
Ki 0.6±n/a nM
CommentsPDSP_235
Citation Dooley, CTSpaeth, CGBerzetei-Gurske, IPCraymer, KAdapa, IDBrandt, SRHoughten, RAToll, L Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J Pharmacol Exp Ther283:735-41 (1997) [PubMed]  Article
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Nociceptin/Orphanin FQ, NOP receptor
Name:Nociceptin/Orphanin FQ, NOP receptor
Synonyms:K3 opiate receptor | KOR-3 | Kappa-type 3 opioid receptor | Nociceptin receptor | ORGC | Orphanin FQ receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:40499.09
Organism:MOUSE
Description:Nociceptin/Orphanin FQ, NOP receptor 0 MOUSE::P35377
Residue:367
Sequence:
MESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCI
GGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALC
KTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGV
PVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLR
GVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRF
CTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTS
ETVPRPA
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BDBM85194
NameBDBM85194
Synonyms:Ac-RYYRWR-NH2
TypeSmall organic molecule
Emp. Form.C49H69N17O9
Mol. Mass.1040.1807
SMILESCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O |r,wU:27.27,50.51,4.3,wD:15.14,39.40,64.67,(-13.35,-1.51,;-12.02,-.73,;-12.02,.81,;-10.7,-1.51,;-9.35,-.73,;-9.35,.81,;-10.7,1.59,;-10.7,3.13,;-9.35,3.92,;-8.02,3.13,;-6.7,3.92,;-8.02,1.57,;-8.02,-1.51,;-8.02,-3.05,;-6.67,-.73,;-5.35,-1.51,;-5.35,-3.05,;-4,-3.84,;-4,-5.38,;-2.67,-6.16,;-1.32,-5.38,;,-6.16,;-1.32,-3.84,;-2.67,-3.05,;-4,-.73,;-4,.81,;-2.67,-1.51,;-1.32,-.73,;-1.32,.81,;,1.57,;,3.13,;1.32,3.92,;2.67,3.13,;4,3.92,;2.67,1.59,;1.32,.81,;,-1.51,;,-3.05,;1.32,-.73,;2.67,-1.51,;2.67,-3.05,;1.32,-3.84,;1.32,-5.38,;2.67,-6.16,;4,-5.38,;5.35,-6.16,;4,-3.84,;4,-.73,;4,.81,;5.35,-1.51,;6.67,-.73,;6.67,.81,;8.02,1.57,;9.51,1.11,;10.37,2.35,;9.51,3.59,;9.89,5.08,;8.75,6.16,;7.27,5.73,;6.89,4.19,;8.02,3.13,;8.02,-1.51,;8.02,-3.05,;9.35,-.73,;10.7,-1.51,;10.7,-3.05,;9.35,-3.84,;9.35,-5.38,;10.7,-6.16,;12.02,-5.38,;12.02,-3.84,;13.36,-6.15,;12.02,-.73,;13.35,-1.51,;12.02,.81,)|
Structure
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