Ki Summary

Reaction Details

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Target

Galanin receptor type 3

Ligand

BDBM50307254

Substrate

n/a

54±n/a nM

Comments

PDSP_1162

Citation

Wang, S; He, C; Hashemi, T; Bayne, M Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes. J Biol Chem 272:31949-52 (1997) [PubMed] Article

More Info.:

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Target

Name:

Galanin receptor type 3

Synonyms:

GALR3_RAT | Galanin R3 | Galanin receptor type 3 | Galnr3 | Galr3

Type:

Enzyme Catalytic Domain

Mol. Mass.:

40439.51

Organism:

RAT

Description:

Galanin R3 GALR3 RAT::O88626

Residue:

370

Sequence:

MADIQNISLDSPGSVGAVAVPVIFALIFLLGMVGNGLVLAVLLQPGPSAWQEPRSTTDLFILNLAVADLCFILCCVPFQAAIYTLDAWLFGAFVCKTVHLLIYLTMYASSFTLAAVSLDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLCFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYSLASRHFRARFRRLWPCGRRRHRHHHRAHRALRRVQPASSGPAGYPGDARPRGWSMEPRGDALRGGGETRLTLSPRGPQ

Inhibitor

Name:

BDBM50307254

Synonyms:

CHEMBL604990 | GWTLNSAGYLLGPPPALALA-CONH2 | M40

Type:

Small organic molecule

Emp. Form.:

C94H145N23O24

Mol. Mass.:

1981.2968

SMILES:

CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O |r|

Structure: