Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-2
Ligand
BDBM50061567
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_691
Citation
 Stauderman, KA; Mahaffy, LS; Akong, M; Veliçelebi, G; Chavez-Noriega, LE; Crona, JH; Johnson, EC; Elliott, KJ; Gillespie, A; Reid, RT; Adams, P; Harpold, MM; Corey-Naeve, J Characterization of human recombinant neuronal nicotinic acetylcholine receptor subunit combinations alpha2beta4, alpha3beta4 and alpha4beta4 stably expressed in HEK293 cells. J Pharmacol Exp Ther 284:777-89 (1998) [PubMed] 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-2
Synonyms:
ACHA2_HUMAN | CHRNA2 | Neuronal acetylcholine receptor; alpha2/beta2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59759.69
Organism:
Homo sapiens (Human)
Description:
Cholinergic, Nicotinic Alpha2Beta2 0 HUMAN::Q15822
Residue:
529
Sequence:
MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
  
Inhibitor
Name:
BDBM50061567
Synonyms:
1,1-Dimethyl-4-phenyl-piperazin-1-ium | CHEMBL134752 | CHEMBL47814 | DMPP | cid_5911
Type:
Small organic molecule
Emp. Form.:
C12H19N2
Mol. Mass.:
191.2921
SMILES:
C[N+]1(C)CCN(CC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: