Reaction Details Report a problem with these data
Target
Stromelysin-1
Ligand
BDBM85281
Substrate
n/a
Meas. Tech.
Fluorimetric Assay
pH
7±0
Temperature
298.15±0 K
IC50
4.4e+4±n/a nM
Citation
 Panico, AM; Vicini, P; Geronikaki, A; Incerti, M; Cardile, V; Crascì, L; Messina, R; Ronsisvalle, S Heteroarylimino-4-thiazolidinones as inhibitors of cartilage degradation. Bioorg Chem 39:48-52 (2011) [PubMed]  Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM85281
Synonyms:
2-(benzo[d]-thiazol-2-ylimino)-5-benzylidenethiazolidin-4-one, 2a
Type:
Small organic molecule
Emp. Form.:
C17H11N3OS2
Mol. Mass.:
337.419
SMILES:
O=C1N\C(S\C1=C\c1ccccc1)=N/c1nc2ccccc2s1
Structure:
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