Reaction Details Report a problem with these data
Target
Glutamine synthetase
Ligand
BDBM85289
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7±0
Ki
140±30 nM
Citation
 Johnson, RC; Boettcher, BR; Cherpeck, RE; Dolson, MG Design and Synthesis of Potent Inhibitors of Glutamine Synthetase Bioorg Chem 18:154-9 (1990)   
Target
Name:
Glutamine synthetase
Synonyms:
GLNA_HUMAN | GLNS | GLUL | Glutamate decarboxylase
Type:
Protein
Mol. Mass.:
42066.51
Organism:
Homo sapiens (Human)
Description:
P15104
Residue:
373
Sequence:
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETGDEPFQYKN
  
Inhibitor
Name:
BDBM85289
Synonyms:
Phosphinothricin analog, 2 (D,L mixture)
Type:
Small organic molecule
Emp. Form.:
C6H13NO4P
Mol. Mass.:
194.146
SMILES:
CC(CC([NH3+])C([O-])=O)P(C)([O-])=O
Structure:
Search PDB for entries with ligand similarity: