Reaction Details Report a problem with these data
Target
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Ligand
BDBM85311
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
6.85±0
Ki
1200000±0.0 nM
IC50
2600000±0.0 nM
Citation
 Milewski, S; Hoffmann, M; Andruszkiewicz, R; Borowski, E Investigation of Mechanism of Nitrogen Transfer in Glucosamine 6-Phosphate Synthase with the Use of Transition State Analogs Bioorg Chem 25:283-296 (1997)   
Target
Name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Synonyms:
GFA1 | GFA1_CANAL | Glucosamine-6- Phosphate Synthase
Type:
Enzyme
Mol. Mass.:
79262.13
Organism:
Candida albicans
Description:
P53704
Residue:
713
Sequence:
MCGIFGYVNFLVDKSKGEIIDNLIEGLQRLEYRGYDSAGIAVDGKLTKDPSNGDEEYMDSIIIKTTGKVKVLKQKIIDDQIDRSAIFDNHVGIAHTRWATHGQPKTENCHPHKSDPKGEFIVVHNGIITNYAALRKYLLSKGHVFESETDTECIAKLFKHFYDLNVKAGVFPDLNELTKQVLHELEGSYGLLVKSYHYPGEVCGTRKGSPLLVGVKTDKKLKVDFVDVEFEAQQQHRPQQPQINHNGATSAAELGFIPVAPGEQNLRTSQSRAFLSEDDLPMPVEFFLSSDPASVVQHTKKVLFLEDDDIAHIYDGELRIHRASTKSAGESTVRPIQTLEMELNEIMKGPYKHFMQKEIFEQPDSAFNTMRGRIDFENCVVTLGGLKSWLSTIRRCRRIIMIACGTSYHSCLATRSIFEELTEIPVSVELASDFLDRRSPVFRDDTCVFVSQSGETADSILALQYCLERGALTVGIVNSVGSSMSRQTHCGVHINAGPEIGVASTKAYTSQYIALVMFALSLSNDSISRKGRHEEIIKGLQKIPEQIKQVLKLENKIKDLCNSSLNDQKSLLLLGRGYQFATALEGALKIKEISYMHSEGVLAGELKHGILALVDEDLPIIAFATRDSLFPKVMSAIEQVTARDGRPIVICNEGDAIISNDKVHTTLEVPETVDCLQGLLNVIPLQLISYWLAVNRGIDVDFPRNLAKSVTVE
  
Inhibitor
Name:
BDBM85311
Synonyms:
GlcN-6-P synthase inhibitor, 4 (racemic mixture)
Type:
Small organic molecule
Emp. Form.:
C6H14NO5P
Mol. Mass.:
211.1528
SMILES:
COC(=O)C(N)CCP(O)(=O)OC
Structure:
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