Reaction Details Report a problem with these data
Target
Beta-catenin-interacting protein 1
Ligand
BDBM275766
Substrate
n/a
Meas. Tech.
Idiopathic Pulmonary Fibrosis (IPF) Primary Screening Assay
IC50
7000±n/a nM
Citation
 Hood, J; KC, SK; Wallace, DM 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof US Patent  US10071086 Publication Date 9/11/2018 
Target
Name:
Beta-catenin-interacting protein 1
Synonyms:
CNBP1_HUMAN | CTNNBIP1 | ICAT | Inhibitor of beta-catenin and Tcf-4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
9168.75
Organism:
Homo sapiens (Human)
Description:
Q9NSA3
Residue:
81
Sequence:
MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTYAGVVNSQLSQLPPHSIDQGAEDVVMAFSRSETEDRRQ
  
Inhibitor
Name:
BDBM275766
Synonyms:
(6S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxooctahydro-1H-pyrazino[1,2-a]pyrimidine-1-carboxamide | ICG-001 | ICG001 | PRI 724 | US10071086, Compound ICG-001
Type:
Small organic molecule
Emp. Form.:
C33H32N4O4
Mol. Mass.:
548.6316
SMILES:
Oc1ccc(CC2N3C(CN(Cc4cccc5ccccc45)C2=O)N(CCC3=O)C(=O)NCc2ccccc2)cc1
Structure:
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