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Target
Lysine-specific histone demethylase 1A [151-852]
Ligand
BDBM111194
Substrate
n/a
Meas. Tech.
LANCE LSD1/KDM1A Demethylase Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
<50±n/a nM
Comments
extracted
Citation
 Wu, L; Courter, JR; He, C; Li, J; Lu, L; Sun, Y; Wang, X; Yao, W; Zhang, C; Zhuo, J Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors US Patent  US9695180 Publication Date 7/4/2017 
Target
Name:
Lysine-specific histone demethylase 1A [151-852]
Synonyms:
AOF2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific histone demethylase 1A
Type:
n/a
Mol. Mass.:
77867.68
Organism:
Homo sapiens (Human)
Description:
ENZO (BML-SE544-0050) which consists of 151-852 aa
Residue:
702
Sequence:
LPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM111194
Synonyms:
US10112950, Example 46 | US10556908, Example 46 | US9695180, 46
Type:
Small organic molecule
Emp. Form.:
C29H32N6O
Mol. Mass.:
480.604
SMILES:
CN(C)Cc1cn2c(-c3ccc(C)cc3)c(nc(OC[C@@H]3CCN(C)C3)c2n1)-c1ccc(cc1)C#N |r|
Structure:
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