Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 2
Ligand
BDBM85397
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_586
Citation
 Okuyama, S; Chaki, S; Kawashima, N; Suzuki, Y; Ogawa, S; Nakazato, A; Kumagai, T; Okubo, T; Tomisawa, K Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001. J Pharmacol Exp Ther 289:926-35 (1999) [PubMed] 
Target
Name:
Corticotropin-releasing factor receptor 2
Synonyms:
CRF-R-2 | CRF-R2 | CRF2 Beta | CRFR-2 | CRFR2_RAT | CRH-R-2 | CRH-R2 | Corticotropin releasing factor receptor | Corticotropin-releasing factor receptor 2 | Corticotropin-releasing hormone receptor 2 | Crf2r | Crhr2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47697.09
Organism:
RAT
Description:
CRF2 Beta 0 RAT::P47866
Residue:
411
Sequence:
MDAALLLSLLEANCSLALAEELLLDGWGEPPDPEGPYSYCNTTLDQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIINYLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNITWFLLQLIDHEVHEGNEVWCRCVTTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIVAWAVGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRSALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
  
Inhibitor
Name:
BDBM85397
Synonyms:
CRA1000
Type:
Small organic molecule
Emp. Form.:
C29H35FN4S
Mol. Mass.:
490.678
SMILES:
CCN(c1nc(C)cc(n1)N1CCC=C(C1)c1cccc(F)c1)c1ccc(CC(C)C)cc1SC |c:14|
Structure:
Search PDB for entries with ligand similarity: