Reaction Details Report a problem with these data
Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM85449
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±0
Temperature
310.15±0 K
Ki
105000±0.0 nM
IC50
110000±0.0 nM
Citation
 Lavrador, K; Allart, B; Guillerm, D; Guillerm, G A new series of S-adenosyl-L-methionine synthetase inhibitors. J Enzym Inhib 13:361-7 (1998) [PubMed]  Article 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AdoMet synthetase 2 | Ams2 | MAT 2 | MAT-II | METK2_RAT | Mat2a | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II | S-Adenosylmethionine Synthase (AdoMet) | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase gamma form | S-adenosylmethionine synthetase isoform type-2
Type:
PROTEIN
Mol. Mass.:
43713.68
Organism:
Rattus norvegicus
Description:
ChEMBL_105118
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM85449
Synonyms:
Epoxy analogue, I(c)
Type:
Small organic molecule
Emp. Form.:
C6H11NO3
Mol. Mass.:
145.1564
SMILES:
C[C@@H]1O[C@H]1C[C@H](N)C(O)=O |r|
Structure:
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