Reaction Details Report a problem with these data
Target
17-beta-hydroxysteroid dehydrogenase type 3
Ligand
BDBM9461
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.45±0
Temperature
310.15±0 K
IC50
1.08e+4±n/a nM
Citation
 Le Lain, R; Nicholls, PJ; Smith, HJ; Maharlouie, FH Inhibitors of human and rat testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD) as potential agents for prostatic cancer. J Enzym Inhib 16:35-45 (2001) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 3
Synonyms:
17-beta-hydroxysteroid dehydrogenase type 3 | DHB3_HUMAN | EDH17B3 | Estradiol 17-beta-dehydrogenase 3 | HSD17B3 | SDR12C2
Type:
Enzyme
Mol. Mass.:
34525.39
Organism:
Homo sapiens (Human)
Description:
P37058
Residue:
310
Sequence:
MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYVAYLKLNTKVR
  
Inhibitor
Name:
BDBM9461
Synonyms:
5,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one | Biochanin A (2) | Biochanin A (BCA) | Biochanin A, 9 | CHEMBL131921 | cid_5280373
Type:
Small organic molecule
Emp. Form.:
C16H12O5
Mol. Mass.:
284.2635
SMILES:
COc1ccc(cc1)-c1coc2cc(O)cc(O)c2c1=O
Structure:
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