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Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Ligand
BDBM275890
Substrate
n/a
Meas. Tech.
Tight-binding assay
pH
7.5±n/a
Ki
41.0±3.4 nM
Comments
extracted
Citation
 Tonge, P; Pan, P Pyridone FabI inhibitors and uses thereof US Patent  US10071965 Publication Date 9/11/2018 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Synonyms:
Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | FABI_STAAR | NADPH-dependent enoyl-ACP reductase | fabI | trans-2-enoyl-[acyl carrier protein] reductase
Type:
Enzyme
Mol. Mass.:
27989.00
Organism:
Staphylococcus aureus
Description:
Q6GI75
Residue:
256
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK
  
Inhibitor
Name:
BDBM275890
Synonyms:
US10071965, Compound PT159
Type:
Small organic molecule
Emp. Form.:
C15H14N2O2
Mol. Mass.:
254.2839
SMILES:
CCc1cc(=O)c(Oc2ccccc2C#N)cn1C
Structure:
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