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Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Ligand
BDBM231620
Substrate
n/a
Meas. Tech.
Tight-binding assay
pH
7.5±n/a
Ki
99.4±2.3 nM
Comments
extracted
Citation
 Tonge, P; Pan, P Pyridone FabI inhibitors and uses thereof US Patent  US10071965 Publication Date 9/11/2018 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Synonyms:
Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | FABI_STAAR | NADPH-dependent enoyl-ACP reductase | fabI | trans-2-enoyl-[acyl carrier protein] reductase
Type:
Enzyme
Mol. Mass.:
27989.00
Organism:
Staphylococcus aureus
Description:
Q6GI75
Residue:
256
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK
  
Inhibitor
Name:
BDBM231620
Synonyms:
CG400549 | US10071965, Compound CG400549
Type:
Small organic molecule
Emp. Form.:
C19H20N2O2S
Mol. Mass.:
340.439
SMILES:
Cc1c(N)cccc1Cn1ccc(OCCc2cccs2)cc1=O
Structure:
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