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Target
Adenosine receptor A3
Ligand
BDBM50034540
Substrate
n/a
Ki
12±n/a nM
Comments
PDSP_7
Citation
 Klotz, KN; Camaioni, E; Volpini, R; Kachler, S; Vittori, S; Cristalli, G 2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol 360:103-8 (1999) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50034540
Synonyms:
2-substituted NECA derivatives, 10 | 5-(6-Amino-2-furan-2-ylethynyl-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid ethylamide | 5-{6-amino-2-[2-(furan-2-yl)ethynyl]-9H-purin-9-yl}-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C18H18N6O5
Mol. Mass.:
398.3727
SMILES:
CCNC(=O)C1OC(C(O)C1O)n1cnc2c(N)nc(nc12)C#Cc1ccco1
Structure:
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