Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2B
Ligand
BDBM50005257
Substrate
n/a
Ki
2.88±n/a nM
Comments
PDSP_706
Citation
 Porter, RH; Benwell, KR; Lamb, H; Malcolm, CS; Allen, NH; Revell, DF; Adams, DR; Sheardown, MJ Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br J Pharmacol 128:13-20 (1999) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2B
Synonyms:
5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
54312.47
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
481
Sequence:
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
  
Inhibitor
Name:
BDBM50005257
Synonyms:
(+)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine | (+)2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine | (+/-)2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine | (-)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine | (-)2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine | 1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine | 2-(2-Methoxy-phenyl)-1-methyl-ethylamine | 2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine | 2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine((-)-DOB) | 2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine((R)-(-)-DOB) | 2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine((S)-(+)-DOB) | 2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine(DOB) | 2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine[R(-)DOB] | 2-(5-Bromo-2,4-dimethoxy-phenyl)-1-methyl-ethylamine | Brolamfetamine | CHEMBL6607 | DOB | Racemic DOB
Type:
Small organic molecule
Emp. Form.:
C11H16BrNO2
Mol. Mass.:
274.154
SMILES:
COc1cc(CC(C)N)c(OC)cc1Br
Structure:
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