Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM85562
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±0
Temperature
298.15±0 K
Ki
65±0.0 nM
Citation
 Scozzafava, A; Saramet, I; Banciu, MD; Supuran, CT Carbonic anhydrase activity modulators: synthesis of inhibitors and activators incorporating 2-substituted-thiazol-4-yl-methyl scaffolds. J Enzym Inhib 16:351-8 (2001) [PubMed] 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4
Type:
Enzyme
Mol. Mass.:
35152.74
Organism:
Bos taurus (bovine)
Description:
Bovine isozyme, isolated from lung microsomes
Residue:
312
Sequence:
MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAKTQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSRAMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQPLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQKPIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLAPVLACLTVGFLR
  
Inhibitor
Name:
BDBM85562
Synonyms:
2-[4-(4-Chlorophenylsulfonyl)-Phenyl}-thiazole-4-yl-methyl-sulfamide, 2b
Type:
Small organic molecule
Emp. Form.:
C16H14ClN3O4S3
Mol. Mass.:
443.948
SMILES:
NS(=O)(=O)NCc1csc(n1)-c1ccc(cc1)S(=O)(=O)c1ccc(Cl)cc1
Structure:
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