Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase transforming protein Src
Ligand
BDBM3354
Substrate
poly(E,Y)
Meas. Tech.
Kinase Inhibition Assay
IC50
400±n/a nM
Citation
 Showalter, HD; Sercel, AD; Leja, BM; Wolfangel, CD; Ambroso, LA; Elliott, WL; Fry, DW; Kraker, AJ; Howard, CT; Lu, GH; Moore, CW; Nelson, JM; Roberts, BJ; Vincent, PW; Denny, WA; Thompson, AM Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners. J Med Chem 40:413-26 (1997) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase transforming protein Src
Synonyms:
P60-Src | SRC_AVISR | V-SRC | pp60v-src
Type:
Enzyme
Mol. Mass.:
58884.32
Organism:
Avian sarcoma virus
Description:
P00525
Residue:
526
Sequence:
MGSSKSKPKDPSQRRCSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKLFGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPPECPESLHDLMCQCWRRDPEERPTFEYLQAQLLPACVLEVAE
  
Inhibitor
Name:
BDBM3354
Synonyms:
2,2 -Diselenobis[N,1-dimethyl-1H-indole-3-carboxamide] | N,1-dimethyl-2-{[1-methyl-3-(methylcarbamoyl)-1H-indol-2-yl]diselanyl}-1H-indole-3-carboxamide | diselenobis(1H-indole) deriv. 23
Type:
Small organic molecule
Emp. Form.:
C22H22N4O2Se2
Mol. Mass.:
532.36
SMILES:
CNC(=O)c1c([Se][Se]c2c(C(=O)NC)c3ccccc3n2C)n(C)c2ccccc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
poly(E,Y)
Synonyms:
n/a
Type:
Random Polymer
Mol. Mass.:
358.43
Organism:
n/a
Description:
poly[(glu)4(tyr)l].
Residue:
3
Sequence:
NA