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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50130278
Substrate
n/a
Ki
10±n/a nM
Comments
PDSP_3798
Citation
 Lovell, PJ; Bromidge, SM; Dabbs, S; Duckworth, DM; Forbes, IT; Jennings, AJ; King, FD; Middlemiss, DN; Rahman, SK; Saunders, DV; Collin, LL; Hagan, JJ; Riley, GJ; Thomas, DR A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970). J Med Chem 43:342-5 (2000) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50130278
Synonyms:
(R)-4-Methyl-1-(2-(1-(naphthalene-1-sulfonyl)-pyrrolidin-2-yl)-ethyl)-piperidine(10) | (R)-4-Methyl-1-{2-[1-(naphthalene-1-sulfonyl)-pyrrolidin-2-yl]-ethyl}-piperidine | 4-Methyl-1-{2-[(R)-1-(naphthalene-1-sulfonyl)-pyrrolidin-2-yl]-ethyl}-piperidine | CHEMBL94984
Type:
Small organic molecule
Emp. Form.:
C22H30N2O2S
Mol. Mass.:
386.551
SMILES:
CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1
Structure:
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