Target
Isoform 2 of Histone lysine demethylase PHF8 (2)
Ligand
BDBM276050
Substrate
n/a
Meas. Tech.
PHF8 Assay
Temperature
298.15±n/a K
IC50
<100±n/a nM
Comments
extracted
Citation
 Chen, YKNie, ZStafford, JAVeal, JM Histone demethylase inhibitors US Patent  US10071984 Publication Date 9/11/2018 
Target
Name:
Isoform 2 of Histone lysine demethylase PHF8 (2)
Synonyms:
Histone lysine demethylase PHF8 (2) | KIAA1111 | NP_055922 | PHF8 | PHF8_HUMAN | ZNF422 | histone lysine demethylase PHF8 isoform 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
113932.27
Organism:
Homo sapiens (Human)
Description:
Q9UPP1-2
Residue:
1024
Sequence:
MASVPVYCLCRLPYDVTRFMIECDMCQDWFHGSCVGVEEEKAADIDLYHCPNCEVLHGPSIMKKRRGSSKGHDTHKGKPVKTGSPTFVRELRSRTFDSSDEVILKPTGNQLTVEFLEENSFSVPILVLKKDGLGMTLPSPSFTVRDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYYSGKREKVLNVISLEFSDTRLSNLVETPKIVRKLSWVENLWPEECVFERPNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVDKCYKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFRFPNFETICWYVGKHILDIFRGLRENRRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEIPETVRTVQLIKDLAREIRLVEDIFQQNVGKTSNIFGLQRIFPAGSIPLTRPAHSTSVSMSRLSLPSKNGSKKKGLKPKELFKKAERKGKESSALGPAGQLSYNLMDTYSHQALKTGSFQKAKFNITGACLNDSDDDSPDLDLDGNESPLALLMSNGSTKRVKSLSKSRRTKIAKKVDKARLMAEQVMEDEFDLDSDDELQIDERLGKEKATLIIRPKFPRKLPRAKPCSDPNRVREPGEVEFDIEEDYTTDEDMVEGVEGKLGNGSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQEAIQGMLCMANLQSSSSSPATSSLQAWWTGGQDRSSGSSSSGLGTVSNSPASQRTPGKRPIKRPAYWRTESEEEEENASLDEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDDAPWSPKARVTPTLPKQDRPVREGTRVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLLKEVEQPRPQDSNLSLTVPAPTVAATPQLVTSSSPLPPPEPKQEALSGSLADHEYTARPNAFGMAQANRSTTPMAPGVFLTQRRPSVGSQSNQAGQGKRPKKGLATAKQRLGRILKIHRNGKLLL
  
Inhibitor
Name:
BDBM276050
Synonyms:
2-[1-(3,4-dihydro-2H-chromen-4-ylmethyl)imidazol-4-yl]-4-(1H-triazol-4-yl)pyridine | US10071984, Example 12 | US10174003, Example 12 | US9896436, Example 12
Type:
Small organic molecule
Emp. Form.:
C20H18N6O
Mol. Mass.:
358.3965
SMILES:
C(C1CCOc2ccccc12)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
Structure:
Search PDB for entries with ligand similarity: