Reaction Details Report a problem with these data
Target
Alpha-2A adrenergic receptor
Ligand
BDBM50027069
Substrate
n/a
Ki
3162.27±n/a nM
Comments
PDSP_1979
Citation
 Brink, CB; Wade, SM; Neubig, RR Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s). J Pharmacol Exp Ther 294:539-47 (2000) [PubMed] 
Target
Name:
Alpha-2A adrenergic receptor
Synonyms:
Alpha-2A adrenergic receptor | adrenergic Alpha2 | adrenergic Alpha2A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48998.96
Organism:
PIG
Description:
adrenergic Alpha2 0 PIG::P18871
Residue:
450
Sequence:
MGSLQPEAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKAGGGGQQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAAAALPGGAERRPNGLGPERGVGRVGAEAEPLPVQLNGAPGEPAPAGPRDADGLDLEESSSSEHAERPPGPRRSERGPRAKSKARASQVKPGDSLPRRGPGAPGPGAPATGAGEERGGVAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
  
Inhibitor
Name:
BDBM50027069
Synonyms:
(2,6-Dimethyl-phenyl)-[1,3]thiazinan-2-ylidene-amine | (5,6-Dihydro-4H-[1,3]thiazin-2-yl)-(2,6-dimethyl-phenyl)-amine | CHEMBL297362 | Xylazine
Type:
Small organic molecule
Emp. Form.:
C12H16N2S
Mol. Mass.:
220.334
SMILES:
Cc1cccc(C)c1N=C1NCCCS1 |w:8.8|
Structure:
Search PDB for entries with ligand similarity: