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Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM276554
Substrate
n/a
Meas. Tech.
NR2B standard assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
3.00±n/a nM
Comments
extracted
Citation
 Chen, G; Chrovian, CC; Coate, HR; Dvorak, CA; Gelin, CF; Hiscox, A; Letavic, MA; Rech, JC; Soyode-Johnson, A; Stenne, B; Wall, JL; Zhang, W Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators US Patent  US10071988 Publication Date 9/11/2018 
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM276554
Synonyms:
5-Bromo-2-[[1-[3-(difluoromethoxy)-4-fluoro-phenyl]triazol-4- | US10071988, Example 494 | US10233173, Example 494
Type:
Small organic molecule
Emp. Form.:
C14H9BrF3N5O2
Mol. Mass.:
416.153
SMILES:
FC(F)Oc1cc(ccc1F)-n1cc(COc2ncc(Br)cn2)nn1
Structure:
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