Reaction Details
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Colony stimulating factor 1 receptor
Ligand
BDBM276744
Substrate
n/a
Meas. Tech.
c-Fms Enzyme Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
2.00±n/a nM
Comments
extracted
Citation
Chen, J; Donahue, M; Lim, H; Lin, R; Salter, R; Wu, J; Gong, Y Substituted pyridine derivatives useful as c-fms kinase inhibitors US Patent US10071991 Publication Date 9/11/2018 More Info.:
Target
Name:
Colony stimulating factor 1 receptor
Synonyms:
CSF1R
Type:
Enzyme Catalytic Domain
Mol. Mass.:
115415.70
Organism:
Canis lupus familiaris (Dog) (Canis familiaris)
Description:
A0A8I3MXT5
Residue:
1044
Sequence:
MEANVACDRPPLQPRSQAPGKKRISPRRRKRKTRETASTAERSVCPAALVPAELAAETPVPCLSLSPASTCRLPTEAMGLGAPLVLLVATAWHVRGVPVIEPRGPELVVEPGTAVTLRCVGNGSVEWEGPISPHWNLDPDSPSSILSTNNATFLNTGTYRCTEPGSPLGGSATIHIYVKDPVRPWKVLTQEVTVLEGQDALLPCLLTDPALEAGVSLMRVRGRPVLRQTNYSFSPWYGFTIHKAQFTETQGYQCSARVGGRTVTSMGIWLKVQKVIPGPPTLTLKPAELVRIQGEAANIECSASNVDVNFDVFLQHEDTKLTIPQQSDFQGNQYQKVLTLELDHVGFQDAGNYTCVATNVRGISSTSMIFRVVESAYLNLTSEQSLLQEVTVGEKVDLQVKVEAYPSLEGYNWTYLGPFSDQQAKLKFVITKDTYRYTSTLSLPRLKPSEAGRYSFLARNTRGGDSLTFELTLLYPPEVRITWTTVNGSDALLCEASGYPQPNVTWLQCRGHTDRCDEAQALVLEDSYSEVLSQEPFHKVIVHSLLAMGTMEHNMTYECRALNSVGNSSQAFRPISIGAHIQPPDEPLFTPVLVTCMSIMVLLLLLLLLLFYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSVSVGQDPGAGAGYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGRVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSVMQACWALEPTRRPTFQQICSLLQEQAQADRREPDYTNLPSSSSSSGSSSEPEEESSSEHLACCEQGDIAQPLLQPNNYQFC
Inhibitor
Name:
BDBM276744
Synonyms:
US10071991, Compound (I-M2-2S,4R) | US10800764, Compound (I-M7-2R,4S) | US11214566, Compound (I-M2-2S,4R)
Type:
Small organic molecule
Emp. Form.:
C27H33N5O4
Mol. Mass.:
491.582
SMILES:
CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@@](C)(C1)C(O)=O |r,c:5|
Structure:
