Target
Colony stimulating factor 1 receptor
Ligand
BDBM276746
Substrate
n/a
Meas. Tech.
c-Fms Enzyme Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
6.60±n/a nM
Comments
extracted
Citation
 Chen, JDonahue, MLim, HLin, RSalter, RWu, JGong, Y Substituted pyridine derivatives useful as c-fms kinase inhibitors US Patent  US10071991 Publication Date 9/11/2018 
Target
Name:
Colony stimulating factor 1 receptor
Synonyms:
CSF1R
Type:
Enzyme Catalytic Domain
Mol. Mass.:
115415.70
Organism:
Canis lupus familiaris (Dog) (Canis familiaris)
Description:
A0A8I3MXT5
Residue:
1044
Sequence:
MEANVACDRPPLQPRSQAPGKKRISPRRRKRKTRETASTAERSVCPAALVPAELAAETPVPCLSLSPASTCRLPTEAMGLGAPLVLLVATAWHVRGVPVIEPRGPELVVEPGTAVTLRCVGNGSVEWEGPISPHWNLDPDSPSSILSTNNATFLNTGTYRCTEPGSPLGGSATIHIYVKDPVRPWKVLTQEVTVLEGQDALLPCLLTDPALEAGVSLMRVRGRPVLRQTNYSFSPWYGFTIHKAQFTETQGYQCSARVGGRTVTSMGIWLKVQKVIPGPPTLTLKPAELVRIQGEAANIECSASNVDVNFDVFLQHEDTKLTIPQQSDFQGNQYQKVLTLELDHVGFQDAGNYTCVATNVRGISSTSMIFRVVESAYLNLTSEQSLLQEVTVGEKVDLQVKVEAYPSLEGYNWTYLGPFSDQQAKLKFVITKDTYRYTSTLSLPRLKPSEAGRYSFLARNTRGGDSLTFELTLLYPPEVRITWTTVNGSDALLCEASGYPQPNVTWLQCRGHTDRCDEAQALVLEDSYSEVLSQEPFHKVIVHSLLAMGTMEHNMTYECRALNSVGNSSQAFRPISIGAHIQPPDEPLFTPVLVTCMSIMVLLLLLLLLLFYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSVSVGQDPGAGAGYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGRVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSVMQACWALEPTRRPTFQQICSLLQEQAQADRREPDYTNLPSSSSSSGSSSEPEEESSSEHLACCEQGDIAQPLLQPNNYQFC
  
Inhibitor
Name:
BDBM276746
Synonyms:
US10071991, Compound (I-M7-2S,4R) | US11214566, Compound (I-M7-2S,4R)
Type:
Small organic molecule
Emp. Form.:
C27H35N5O3
Mol. Mass.:
477.5985
SMILES:
CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@](C)(CO)C1 |r,c:5|
Structure:
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