Reaction Details Report a problem with these data
Target
Sigma-54-dependent Fis family transcriptional regulator
Ligand
BDBM276764
Substrate
n/a
Meas. Tech.
Quorum sensing assay
IC50
69220±1420 nM
Citation
 Li, S; Xiao, J; Sun, Q; Zhong, W; Wang, L; Zheng, Z; Xie, Y; Li, X; Zhou, X; Wang, X; Cao, R N-sulfonyl homoserine lactone derivatives, preparation method and use thereof US Patent  US10071994 Publication Date 9/11/2018 
Target
Name:
Sigma-54-dependent Fis family transcriptional regulator
Synonyms:
Quorum-sensing regulator protein F | qseF_2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49423.80
Organism:
Chromobacterium violaceum
Description:
A0A1R0MIV1
Residue:
458
Sequence:
MKYLPILVVEDDADLREAIVDTLSLAGYPTLEAADGGSALQKLAQEPVGLIISDAQMAPMDGYDLFEEAKKRYPGVPFILMTAYGVIERAIELLRAGAAHYLLKPFEPQSLLAEVDKHLLAMPGDGGGEVVAESAAMRQLFALAGRVAQSDASVMISGPSGSGKEVLARYIHRHSKRGSGPFVAVNCAAIPDNLLESTLFGHERGAFTGAAQALPGKFEQAQGGTILLDEVTEMPLPLQAKLLRVLQEREVERIGATRTIKLDIRVLATSNRDLQAAVEAGNFREDLYFRLNVFPLRIPALAERPEDILPLARFLLKKHAEAAGRASLVFSRDAERHLTAYSWEGNIRELDNVVQRAVILAAGAEILAADLMLGDIAGVGQFTRAESESDSSVSGETDMKTLEKRHILETLAAVGGVKKLAAEKLGISERTLRYKLQRYRDEDAADAGGNVPEGSGTE
  
Inhibitor
Name:
BDBM276764
Synonyms:
(s)-3-methyl-N-(4-(N-(2-oxotetrahydrofuran-3-yl)sulfamoyl)phenyl)thiophene-2-carboxamide | US10071994, Compound 8
Type:
Small organic molecule
Emp. Form.:
C16H16N2O5S2
Mol. Mass.:
380.439
SMILES:
Cc1ccsc1C(=O)Nc1ccc(cc1)S(=O)(=O)NC1CCOC1=O
Structure:
Search PDB for entries with ligand similarity: