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Target
Neuromedin-K receptor
Ligand
BDBM85845
Substrate
n/a
Ki
17.9±n/a nM
Comments
PDSP_2451
Citation
 Hay, DW; Giardina, GA; Griswold, DE; Underwood, DC; Kotzer, CJ; Bush, B; Potts, W; Sandhu, P; Lundberg, D; Foley, JJ; Schmidt, DB; Martin, LD; Kilian, D; Legos, JJ; Barone, FC; Luttmann, MA; Grugni, M; Raveglia, LF; Sarau, HM Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs. J Pharmacol Exp Ther 300:314-23 (2002) [PubMed]  Article 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK-3 receptor | NK-3R | NK3R_MOUSE | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin NK3 | Neuromedin-K receptor | Tac3r | Tachykinin receptor 3 | Tacr3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51047.50
Organism:
mouse
Description:
P47937
Residue:
452
Sequence:
MASVPTGENWTDGTAGVGSHTGNLSAALGITEWLALQAGNFSSALGLPVTSQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLVNFIYGVHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLYDPSEGDPAKSSRKKRAVPRDPSANGCSHREFKSASTTSSFISSPYTSVDEYS
  
Inhibitor
Name:
BDBM85845
Synonyms:
N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)quinoline-4-carboxamide | SB 235375
Type:
Small organic molecule
Emp. Form.:
C27H24N2O4
Mol. Mass.:
440.4905
SMILES:
CC[C@H](NC(=O)c1c(OCC(O)=O)c(nc2ccccc12)-c1ccccc1)c1ccccc1
Structure:
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