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Target
Beta-secretase 2
Ligand
BDBM276800
Substrate
n/a
Meas. Tech.
BACE-2 Assay
pH
5±n/a
Ki
124±n/a nM
Comments
extracted
Citation
 Wu, W; He, S; Walsh, SP; Cumming, JN Iminothiadiazine dioxides bearing an amine-linked substituent as BACE inhibitors, compositions, and their use US Patent  US10071998 Publication Date 9/11/2018 
Target
Name:
Beta-secretase 2
Synonyms:
AEPLC | ALP56 | ASP1 | ASP21 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | BACE2 | BACE2_HUMAN | Beta secretase 2 | Beta-secretase (BACE) | Beta-secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2)
Type:
Protein
Mol. Mass.:
56171.20
Organism:
Homo sapiens (Human)
Description:
Q9Y5Z0
Residue:
518
Sequence:
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
  
Inhibitor
Name:
BDBM276800
Synonyms:
(R)-5-(5-(((R)-3-chloro-6,7-dihydro-5H-cyc1openta[b]pyridin-5-yl)amino)-2-fluorophenyl)-3-imino-2,5-dimethyl-1,2,4-thiadiazinane 1,1-dioxide | US10071998, Example 15
Type:
Small organic molecule
Emp. Form.:
C19H21ClFN5O2S
Mol. Mass.:
437.919
SMILES:
CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(N[C@@H]2CCc3ncc(Cl)cc23)ccc1F |r|
Structure:
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