Reaction Details Report a problem with these data
Target
Arachidonate 12-lipoxygenase, 12R-type
Ligand
BDBM86010
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±0
Temperature
298.15±0 K
Ki
5.76e+4± 2.6e+3 nM
Citation
 Hasan, A; Khan, KM; Sher, M; Maharvi, GM; Nawaz, SA; Choudhary, MI; Atta-ur-Rahman, A; Supuran, CT Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones. J Enzyme Inhib Med Chem 20:41-7 (2005) [PubMed]  Article 
Target
Name:
Arachidonate 12-lipoxygenase, 12R-type
Synonyms:
ALOX12B | LX12B_HUMAN | Lipoxygenase
Type:
Enzyme
Mol. Mass.:
80366.80
Organism:
Homo sapiens (Human)
Description:
O75342
Residue:
701
Sequence:
MATYKVRVATGTDLLSGTRDSISLTIVGTQGESHKQLLNHFGRDFATGAVGQYTVQCPQDLGELIIIRLHKERYAFFPKDPWYCNYVQICAPNGRIYHFPAYQWMDGYETLALREATGKTTADDSLPVLLEHRKEEIRAKQDFYHWRVFLPGLPSYVHIPSYRPPVRRHRNPNRPEWNGYIPGFPILINFKATKFLNLNLRYSFLKTASFFVRLGPMALAFKVRGLLDCKHSWKRLKDIRKIFPGKKSVVSEYVAEHWAEDTFFGYQYLNGVNPGLIRRCTRIPDKFPVTDDMVAPFLGEGTCLQAELEKGNIYLADYRIMEGIPTVELSGRKQHHCAPLCLLHFGPEGKMMPIAIQLSQTPGPDCPIFLPSDSEWDWLLAKTWVRYAEFYSHEAIAHLLETHLIAEAFCLALLRNLPMCHPLYKLLIPHTRYTVQINSIGRAVLLNEGGLSAKGMSLGVEGFAGVMVRALSELTYDSLYLPNDFVERGVQDLPGYYYRDDSLAVWNALEKYVTEIITYYYPSDAAVEGDPELQSWVQEIFKECLLGRESSGFPRCLRTVPELIRYVTIVIYTCSAKHAAVNTGQMEFTAWMPNFPASMRNPPIQTKGLTTLETFMDTLPDVKTTCITLLVLWTLSREPDDRRPLGHFPDIHFVEEAPRRSIEAFRQRLNQISHDIRQRNKCLPIPYYYLDPVLIENSISI
  
Inhibitor
Name:
BDBM86010
Synonyms:
Chalcone, 10
Type:
Small organic molecule
Emp. Form.:
C15H11ClO2
Mol. Mass.:
258.7
SMILES:
Oc1ccc(Cl)cc1C(=O)\C=C\c1ccccc1
Structure:
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