Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 5

Ligand

BDBM50089038

Substrate

n/a

0.24±n/a nM

Comments

PDSP_7139

Citation

Holmberg, SK; Mikko, S; Boswell, T; Zoorob, R; Larhammar, D Pharmacological characterization of cloned chicken neuropeptide Y receptors Y1 and Y5. J Neurochem 81:462-71 (2002) [PubMed] Article

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Target

Name:

Neuropeptide Y receptor type 5

Synonyms:

NPY-Y5 | NPY5R

Type:

Enzyme Catalytic Domain

Mol. Mass.:

50065.15

Organism:

Chicken

Description:

Q8QFM2

Residue:

443

Sequence:

MDLGFKDYTNRTPTKNTSATTKNFSAWEDYKSSVDDIQYFLIGLYTLISLAGFVGNLLVLTALTKRKQKTIINILIGNLAFSDILVVLFCSPFTLTSVLLDRWMFGTVMCHIMPFLQCTSVLVSTLMLISIAAVRYRMVKYPLSSNLTAKHGYFLIVIIWAVGCAICSPLPVFHKIVDLHKTLNLEALENRLLCIESWPSDSYRIAFTISLLLMQYILPLVCLTASHTSVCRSVGSRLSSKEGKFQENEMINLTLHPSKSAGTEAQPSSHTSWSCALVRKHHRRYSKKTSTVMPAILRQQQDADFRDLPETSGTEKSQLSSSSKFIPGVPICFEMKPEENTEIQDMITVSQSIIRIKTRSRRVFCRLTVLILVFGFSWMPLHLFHIVTDFNATLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNSIKADLMSLIPCCQIL

Inhibitor

Name:

BDBM50089038

Synonyms:

CGP 71683 | CGP-71683A | CHEMBL17645 | N-{[(1r,4r)-4-{[(4-aminoquinazolin-2-yl)amino]methyl}cyclohexyl]methyl}naphthalene-1-sulfonamide (Compound 1) | Naphthalene-1-sulfonic acid {4-[(4-amino-quinazolin-2-ylamino)-methyl]-cyclohexylmethyl}-amide

Type:

Small organic molecule

Emp. Form.:

C26H29N5O2S

Mol. Mass.:

475.606

SMILES:

Nc1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12 |wU:6.5,wD:9.9,(2.92,.42,;2.94,-1.13,;4.28,-1.89,;4.29,-3.44,;5.63,-4.22,;6.96,-3.45,;8.29,-4.21,;9.63,-3.44,;10.96,-4.22,;10.95,-5.76,;12.28,-6.54,;13.77,-6.13,;14.86,-7.21,;13.98,-8.47,;15.7,-5.91,;16.12,-8.05,;17.24,-7,;18.73,-7.45,;19.09,-8.94,;17.97,-9.99,;18.33,-11.48,;17.22,-12.56,;15.73,-12.11,;15.38,-10.62,;16.49,-9.56,;9.62,-6.51,;8.29,-5.75,;2.95,-4.23,;1.61,-3.45,;.26,-4.23,;-1.07,-3.46,;-1.07,-1.9,;.26,-1.13,;1.61,-1.9,)|

Structure: