Reaction Details Report a problem with these data
Target
Metabotropic glutamate receptor 2
Ligand
BDBM277128
Substrate
n/a
Meas. Tech.
Biological Assays
IC50
33700±n/a nM
Citation
 Arasappan, A; Bungard, CJ; Frie, JL; Han, Y; Hoyt, SB; Manley, PJ; Meissner, RS; Perkins, JJ; Sebhat, IK; Wilkening, RR; Leavitt, KJ Tetrahydronaphthyridine derivatives as mGluR2-negative allosteric modulators, compositions, and their use US Patent  US10072003 Publication Date 9/11/2018 
Target
Name:
Metabotropic glutamate receptor 2
Synonyms:
GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2
Type:
Enzyme
Mol. Mass.:
95584.88
Organism:
Homo sapiens (Human)
Description:
Q14416
Residue:
872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
  
Inhibitor
Name:
BDBM277128
Synonyms:
7-[(1-methyl-1H-1,2,3-triazol-5-yl)methyl]- 4-(2,4,6-trifluorophenyl)-5,6,7,8-tetrahydro- 1,7-naphthyridine-2-carboxamide | US10072003, Example 2-21
Type:
Small organic molecule
Emp. Form.:
C19H17F3N6O
Mol. Mass.:
402.3731
SMILES:
Cn1nncc1CN1CCc2c(C1)nc(cc2-c1c(F)cc(F)cc1F)C(N)=O |(-2.82,.77,;-4.15,1.54,;-5.61,1.06,;-6.52,2.31,;-5.61,3.56,;-4.15,3.08,;-2.82,3.85,;-1.48,3.08,;-1.48,1.54,;-.15,.77,;1.18,1.54,;1.18,3.08,;-.15,3.85,;2.52,3.85,;3.85,3.08,;3.85,1.54,;2.52,.77,;2.52,-.77,;1.18,-1.54,;-.15,-.77,;1.18,-3.08,;2.52,-3.85,;2.52,-5.39,;3.85,-3.08,;3.85,-1.54,;5.19,-.77,;5.19,3.85,;6.52,3.08,;5.19,5.39,)|
Structure:
Search PDB for entries with ligand similarity: