Reaction Details
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cholinergic receptor, nicotinic, alpha 1 (Muscle) isoform X1
Ligand
BDBM86044
Substrate
n/a
Ki
100±n/a nM
Comments
PDSP_2903
Citation
Avalos, M; Parker, MJ; Maddox, FN; Carroll, FI; Luetje, CW Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine. J Pharmacol Exp Ther 302:1246-52 (2002) [PubMed] Article More Info.:
Target
Name:
cholinergic receptor, nicotinic, alpha 1 (Muscle) isoform X1
Synonyms:
Cholinergic, Nicotinic Alpha3Beta2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51980.65
Organism:
Xenopus
Description:
Cholinergic, Nicotinic Alpha3Beta2 0 Xenopus::F6RLM5
Residue:
457
Sequence:
MDYTASCLIFFFIAAGPVFSSDHETRLIGDLFANYNKVVRPVETYKDQVVVTVGLQLIQLINVDEVNQIVSTNIRLKQQWVDVNLKWDPAKYGGVKKLRIPSSEVWCPDLVLYNNADGDFAISKDTKILLEHTGKITWTPPAIFKSYCEIIVTHFPFDQQNCSMKFGTWTYDGTLVVINPDRDRPDLSNFMASGEWMMKDYRCWKHWVYYTCCPDKPYLDITYHFVLQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHTMPPWVRKIFIDTIPNIMFFSTMKRPSQEKQPQTTFAEEMDISDISGKLGPAAVTYQSPALKNPDVKSAIEGIKYIAETMKSDQESNKASEEWKFVAMVLDHILLAVFMTVCVIGTLAVFAGRIIEMNMQD
Inhibitor
Name:
BDBM86044
Synonyms:
NTEP
Type:
Small organic molecule
Emp. Form.:
C12H13F3N2O3S
Mol. Mass.:
322.303
SMILES:
FC(F)(F)S(=O)(=O)Oc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:11:14:17.18:20|
Structure:
