Reaction Details
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neuronal acetylcholine receptor subunit alpha-4
Ligand
BDBM50119631
Substrate
n/a
Ki
100±n/a nM
Comments
PDSP_2901
Citation
Avalos, M; Parker, MJ; Maddox, FN; Carroll, FI; Luetje, CW Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine. J Pharmacol Exp Ther 302:1246-52 (2002) [PubMed] Article More Info.:
Target
Name:
neuronal acetylcholine receptor subunit alpha-4
Synonyms:
Cholinergic, Nicotinic Alpha4Beta2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81710.63
Organism:
Xenopus
Description:
Cholinergic, Nicotinic Alpha4Beta2 0 Xenopus::A9JRM3
Residue:
734
Sequence:
MGARIPRGARLSANMGARIPCGARLSANMGARIPCGARLSANMGARIPSGARLSANMGARIPRGASLSANMGARIPSGARLSANMGARIPSGARLSANMGARIPRGARLSANMGARAQTLLLLLGGFFSTAFCHIETRAHAEERLLKGLFSGYNKWSRPVANISDAVMVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPLEYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRIKWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDRAKIDLISMHSHVDQLDYWESGEWVIVNAVGNYNIKKYECCTEIYSDITYSFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLFIIITVFVLNVHHRSPRTHTMPAWVRRTFLDVVPRVLFMKRPAKDNCKKLIESLHARSFNPPPRLWSEAEIEPAFASSSSASPTSQRPSPTSSCCHQLEQSPNAQVFCKSPSGQYSMLCEESALTSCPSPKPETKLLSEAQPNLMPKVRSVSVQQMYTPKEANEGAVRCRSRSIQYCFLHEDFSQANGQASSSPVAQKGNGNEPQPSSHTSPCTCKPKSQEKPVDPSQGAKTVNAKEHHVLLMSPSLKLAIEGVHYIADHLRAEDADFSVKQDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
Inhibitor
Name:
BDBM50119631
Synonyms:
5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-2-ol | CHEMBL144958 | NOHEP
Type:
Small organic molecule
Emp. Form.:
C11H14N2O
Mol. Mass.:
190.2417
SMILES:
O=c1ccc(c[nH]1)[C@H]1CC2CCC1N2 |THB:4:7:13:11.10|
Structure:
